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Neuropsychiatric Lupus Syndromes: American College of Rheumatology Classification

The American College of Rheumatology has delineated 19 specific presentations of SLE affecting the nervous system. Twelve involve the CNS, of which five are behavioral (acute confusional state, mood disorder, anxiety disorder, psychosis, cognitive dysfunction), three are function related (movement disorder, myelopathy, demyelinating state), and four are classified as others (aseptic meningitis, cardiovascular state, headache, seizure disorders). Seven involve the peripheral nervous system, of which four are nerve related (mononeuropathy, cranial neuropathy, polyneuropathy, autonomic neuropathy) and three are classified as others (Guillain-Barre syndrome, myasthenia gravis, plexopathy). Just about any part of the brain can be affected by any of the lupus syndromes.


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  1. aboutlupus posted this
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